Studies for Medicinal Chemistry
integrating approach for developing countries
and C. Robin Ganellin
(eds.) IUPAC, 2006
The exercises for Practical Studies in Medicinal Chemistry presented
here derive from an initiative of the IUPAC
Subcommittee on Medicinal Chemistry and Drug Development for the
purpose of providing experimental studies for research into therapeutic
drugs regardless of the academic level of the universities.
These laboratory exercises are representative of the field of Medicinal
Chemistry, easy to reproduce, and, in many cases, interdisciplinary.
Some of them take natural products as the work material, and none of
them present any difficulties with regard to their realization or to
safety conditions. Responsibility for the exercises resides with the
authors, who have followed the instructions they were given.
The majority of the exercises have been written in English, and most
are also in Spanish or Portuguese. Our intention is to facilitate the
participation of as many researchers as possible. This Web site is open
to all readers in general, professors, and students. Although this last
group might not have a good command of English, it is important that
they see IUPAC as an open door to the fascinating world of Medicinal
The practical exercises found here may be freely reproduced provided
that the name of the contributing author and the IUPAC source are always
quoted. If you want to publish any or all of these exercises to be used
in an exercise workbook, please send two copies to the coordinator of
this initiative for reporting and filing.
These exercises may be translated into any language. In this case,
we suggest that you send the translated material to the coordinator
in electronic format as well as on paper so that, if possible, these
translated exercises may be included in later updated versions of the
New practical exercises may be added while the IUPAC Web site is still
active. The idea is that this site remains active for the next five
years. Comments and suggestions, translations into other languages,
the inclusion of workbooks, etc. will be added.
All activity will be channeled through the coordinator.
One purpose of this initiative is to unite the efforts of all countries
and centers regardless of their economic development. This initiative
also has special interest in malaria, tuberculosis etc., diseases that
affect large populations. Any contribution to this initiative is welcome.
This work is a continuation of a pilot initiative by Drs. Barreiro,
Fontes Prado and Monge, under the patronage of CYTED (Ciencia y Tecnología
para el Desarrollo en América Latina). The universal dimensions
of this initiative have only been made possible due to the patronage
The Members of the Task Group that was formed within IUPAC are as follows:
Prof. E. Barreiro
Prof. A. Fontes Prado
Prof. C. Wermuth
Prof. E. Breuer
Prof. A. Buschauer
Prof. H. Stark
The collaborators in this edition of the Practical Studies are:
Prof. R. Ganellin
Dr. J. Proudfoot
Dr. M. Chorghade
Prof. P. Erhardt
Dr. J. Fischer
Prof. C. Wermuth
We would like to express our sincere gratitude to L. Stokes and E.
Berjón for the translation and organization of the original documents.
All of the coordinators and authors wish to thank Fabienne Meyers and
Cheryl Wurzbacher for their professional and delicate correction of
the manuscript, most important in this work in which researchers from
a wide range of non-Anglo-Saxon countries have participated.
Antonio Monge and C. Robin Ganellin
Pamplona and London
We invite you to collaborate in this initiative by recommending the
Web site to your Medicinal Chemistry students for their use in carrying
out practical experiments. We also ask for your cooperation in further
improving the Web site.
Dr. Antonio Monge
Universidad de Navarra
E-31008 Pamplona (Navarra),
TEL: + (948) 42 5653
FAX: + (948) 42 5652
Dr. C. Robin Ganellin
University College London
Department of Chemistry
Christopher Ingold Laboratory
20 Gordon Street
London, WC1H OAJ, UK
TEL: + 207-679-4624
FAX: + 207-679-7463