Advances in biocatalytic synthesis. Enzyme-triggered asymmetric
cascade reactions
S. M. Glueck, S. F. Mayer, W. Kroutil, and K. Faber*
Department of Chemistry, Organic and Bioorganic Chemistry,
University of Graz, Heinrichstrasse 28, A-8010 Graz, Austria
Abstract:
Organic compounds can be transformed through enzyme-triggered domino
(or cascade) reactions via several (inseparable) consecutive steps in
an asymmetric fashion to yield nonracemic products. Despite the fact
that these sequences often involve the occurrence of highly reactive
unstable intermediates, the overall efficiency of these processes can
be high, provided that the reaction rates of the individual steps match
each other in order to minimize side reactions.
*Lecture presented at the IUPAC Workshop, Impact of
Scientific Developments on the Chemical Weapons Convention, Bergen,
Norway, 30 June-3 July 2002. Other presentations are published in this
issue, pp. 2229-2322.
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