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Pure Appl. Chem., 2002, Vol. 74, No. 1, pp. 129-133

Nickel-catalyzed cyclizations of alkynyl enones and alkynyl enals

John Montgomery, Kande K. D. Amarasinghe, Sanjoy K. Chowdhury, Eric Oblinger, Jeongbeob Seo and Alexey V. Savchenko

Department of Chemistry, Wayne State University, Detroit, MI 48202-3489, USA

Abstract: Substrates that possess an a,b-unsaturated carbonyl tethered to an alkyne have been utilized in a variety of nickel-catalyzed processes. Depending on ligand structure, reagent structure, reaction conditions, and workup conditions, several different monocyclic and bicyclic ring systems may be accessed from a common substrate. Evidence for a nickel metallacycle as a common intermediate is provided.