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Pure Appl. Chem., 2008, Vol. 80, No. 5, pp. 881-890

http://dx.doi.org/10.1351/pac200880050881

New methods in asymmetric catalysis based on new hemi-labile bidentate ligands

André B. Charette, Alexandre Côté, Jean-Nicolas Desrosiers, Isabelle Bonnaventure, Vincent N. G. Lindsay, Caroline Lauzon, Jad Tannous and Alessandro A. Boezio

Department of Chemistry, University of Montréal, Montréal, Québec H3C 3J7, Canada

Abstract: Chiral bidentate hemi-labile bis(phosphine) monoxide ligands were shown to be quite effective in various copper-catalyzed transformations. Among them, the nucleophilic addition to imines, the conjugate addition to α,β-unsaturated nitro derivatives, and the conjugate reduction of α,β-unsaturated sulfones generally gave good to excellent yields and high enantiomeric excesses.