Pure Appl. Chem., 2010, Vol. 82, No. 3, pp. 577-582
http://dx.doi.org/10.1351/PAC-CON-09-11-06
Published online 2010-02-14
Asymmetric synthesis of aminophosphonic acids mediated by chiral sulfinyl auxiliary: Recent advances
Abstract:
New approaches to asymmetric synthesis of α-, β- and γ-aminophosphonic acids using enantiopure p-toluenesulfinimines as key reagents are reported. The utility of the devised methods is illustrated by the syntheses of enantiomeric aminophosphonic acids such as AP4, AP3, and its 3-amino isomer.
Keywords
aminophosphonic acids; asymmetric syntheses; bioactivity; chiral sulfinimines; diastereoselectivity.