Title: Practical studies for Medicinal Chemistry - An integrating
approach for developing countries
Barreiro, E. Breuer,
A. Buschauer, A.
Fontes Prado, R.
Ganellin, H. Stark,
and C. Wermuth
Completion Date: 2006 - project completed
To provide the developing countries with a practical textbook
containing practical experiments to assist studies in Medicinal Chemistry
- It should take into account the special characteristics of these
societies, such as taking advantage of the natural resources, lack
of economic means for obtaining reagents, materials, etc. The idea
is to also provide a foundation for post graduate studies that will
facilitate the training of medicinal chemists so that they can conduct
research into the discovery and development of drugs to treat indigenous
diseases, such as tuberculosis, malaria, leprosy, and Chagas. Since
these diseases principally affect the developing countries and receive
little attention in the pharmaceutical industry of the developed countries,
it is important to assist the developing countries to tackle their
To prepare the book "Practical Studies for Medicinal Chemistry
Students. An integrated approach for developing countries" -
The book will be prepared in paper form and will also be accessible
via the IUPAC web page, being able to download any or all of its pages
free of charge.
The text will be written in English but some texts will also
be in Spanish and Portuguese, when provided by the authors. This allows
accessibility to students who are not fluent in English. The text
would be of integrating character, from disciplines that converge
in R&D of Medicinal Chemistry: organic synthesis, natural product,
isolation, structural identification, and structure-activity relationships;
biological activities. The experiments provided would be such that
they could be carried out with easily accessible starting materials
(natural products from the area, for example) and economic reagents,
and low-cost instrumentation and techniques.
These practical texts would be applicable to diseases which are indigenous
to the developing countries, for example, isolation of products with
antimalaria activity, based on products of natural origin; low-cost
synthesis of antituberculosis products, etc.
The task group members are specialists in the different areas corresponding
to the book material.An initial approach in Latin America and for
Spanish- and Portuguese-speaking countries was recently presented
by Dr. Barreiro and Dr. Fortes, within a R&D program, coordinated
by A. Monge. This text will be the embryo of the future version to
be prepared for IUPAC.
The favorable reception of this initiative allows for a more extensive
proposal with universal character. The manual would be valid for universal
use, regardless of the development stages of the societies.
Integrating Practical Studies
· Chemical synthesis
· Biological activity
· Predictive calculation of A.D.M.E
· Predictive calculation of solubility, ...
Low Cost Practical Studies
· Regarding equipment (instruments, apparatus, ...)
· Regarding reagents
· Regarding software, ...
Practical Studies Based on Natural Products and
Products of Synthesis
· Possibility to adapt experiments to native natural products
March 2005 - The project is progressing according to plan.
A first report was presented in the Subcommittee Medicinal Chemistry
meeting on 13 Feb 2005.
The call for submitting practical studies is set for 1 August 2005.
December 2006 - compilation completed
Last Update: 15 December 2006
<project announcement published