Vol. 23, No. 2
Book from The Royal Society of Chemistry
Principles and Practices of Method Validation. Edited by A.
Fajgelj and Á. Ambrus. Hardcover, 2000, x + pp. 1-305. ISBN 0-85404-783-2,
This book contains lectures presented at the International Workshop
on Principles and Practices of Method Validation, held 4-6 November
1999 in Budapest, Hungary (see
report by Dr. Ales Fajgelj and Dr. Árpád Ambrus in CI,
Vol. 22, No. 3, pp. 71-73, 2000). The International Association
of Official Analytical Chemists (AOAC International), Food and Agriculture
Organization (FAO), International Atomic Energy Agency (IAEA), IUPAC,
and the Plant Health and Soil Conservation Station of Budapest cooperated
in the organization of this event.
Principles and Practices of Method Validation is an overview of the
most recent approaches used for method validation in cases where a large
number of analytes are determined from a single aliquot and where a
large number of samples are to be analyzed. Much of the content relates
to the validation of new methods for pesticide residue analysis in foodstuffs
and water, but the principles can be applied to similar fields of analysis.
Different chromatographic methods are discussed, including estimation
of various effects (e.g., matrix-induced effects and the influence of
equipment setup). Methods used for routine purposes and validation of
analytical data in the research and development environment are documented.
Legislation covering the EU Guidance on residue analytical methods,
an extensive review of existing in-house method validation documentation,
and guidelines for single-laboratory validation of analytical methods
for trace-level concentrations of organic chemicals are also included.
With contributions from experts in the field, any practicing analyst
dealing with method validation will find the examples presented in this
book to be a useful source of technical information.
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