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Chemistry International
Vol. 23, No. 2
March 2001


New Book from The Royal Society of Chemistry

Principles and Practices of Method Validation. Edited by A. Fajgelj and Á. Ambrus. Hardcover, 2000, x + pp. 1-305. ISBN 0-85404-783-2, GBP 59.50.


This book contains lectures presented at the International Workshop on Principles and Practices of Method Validation, held 4-6 November 1999 in Budapest, Hungary (see report by Dr. Ales Fajgelj and Dr. Árpád Ambrus in CI, Vol. 22, No. 3, pp. 71-73, 2000). The International Association of Official Analytical Chemists (AOAC International), Food and Agriculture Organization (FAO), International Atomic Energy Agency (IAEA), IUPAC, and the Plant Health and Soil Conservation Station of Budapest cooperated in the organization of this event.

Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases where a large number of analytes are determined from a single aliquot and where a large number of samples are to be analyzed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water, but the principles can be applied to similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects (e.g., matrix-induced effects and the influence of equipment setup). Methods used for routine purposes and validation of analytical data in the research and development environment are documented.

Legislation covering the EU Guidance on residue analytical methods, an extensive review of existing in-house method validation documentation, and guidelines for single-laboratory validation of analytical methods for trace-level concentrations of organic chemicals are also included. With contributions from experts in the field, any practicing analyst dealing with method validation will find the examples presented in this book to be a useful source of technical information.

The Royal Society of Chemistry is a learned and professional society with a worldwide membership of 46 000. It has as its main objective the advancement of the science of chemistry and its applications, and the maintenance of high standards of competence and integrity among practicing chemists. The society has been involved with the publication of scientific literature since 1841. Surplus cash generated from sales funds the promotion of chemistry.

To order, contact Sales and Customer Care, The Royal Society of Chemistry, Thomas Graham House, Science Park, Milton Road, Cambridge, England CB4 0WF, UK; E-mail:; Tel.: +44 1223 420066; Fax: +44 1223 423429; Web site: or



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