Practice of Medicinal Chemistry (MC) in the New Millennium
(reproduced from Section 3–Evolving Drug Discovery and Development Process)
The most striking differences from the long-standing practice of MC are: (i) Data reduction of huge amounts of rapidly derived highthroughput screening (HTS) biological results; (ii) Greater emphasis upon multi-technique chemical structure considerations; and most importantly, (iii) The simultaneous attention given to all of the ADMET-related parameters along with efficacy and efficacyrelated selectivity during lead compound selection and further design or enhancement coupled with an expanding knowledge base that offers the possibility for achieving synergistic benefits by taking advantage of various combinations of multi-agent, prodrug, soft drug and/or multi-valent drug strategies.

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