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IUPAC/SCOPE Project

Environmental implications of endocrine active substances: Present state-of-the-art and future research needs

> Access to Project Description

DRAFT CONTENTS

Topic 1 - Molecular Mode of Action of Nuclear Receptors; Fundamentals for Understanding the Action of Endocrine Active Substances
Coordinators: Dr. W. Kelce and Dr. Kenneth Korach (NIEHS, Research Triangle Park, NC, USA)

  1. Nuclear receptor superfamily (nuclear receptor superfamily members, structure similarity/diversity, function DNA gene response elements and sequence recognitions)
    Prof. P. Chambon (France)
  2. Mode of action of coactivators and corepressors
    Dr. B. O'Malley (USA)
  3. Function and mode of action of nuclear receptors; estrogen, progesterone and vitamin D
    Dr. D. McDonnell (USA)
  4. Biological function and mode of action of the androgen receptor
    Dr. E. Wilson (USA)
  5. Biological function and mode of action of nuclear receptors; glucocorticoid and mineralcorticoid
    Dr. G. Schutz (France)
  6. Biological function and mode of action of retinoid nuclear receptors
    Dr. H. Gronemeyer (France)
  7. Biological function and mode of action of orphan nuclear and thyroid hormone receptors
    Dr. R. Evans (USA)
  8. Molecular mechanisms of cross-talk between growth factors and nuclear receptor signaling
    Dr. D. Picard (Switzerland)
  9. Nuclear hormone receptor action through classical and alternative target genes
    Dr. P. Kushner (USA)
  10. Nuclear receptor action involved with gonadal differentiation
    Dr. I. Hughes (USA)
  11. Hereditary diseases related to nuclear receptor gene mutation
    Dr. L. Jamenson (USA)
  12. Interaction of exogenous endocrine active substances with nuclear receptors
    Dr. J. Katzenellenbogen (USA)

Topic 2 - Environmental Fate and Metabolism of Endocrine Active Substances
Coordinator: Prof. W. Klein

  1. Introduction
    Prof. W. Klein
  2. Technologies for the Detection of Endocrine Active Substances in Food and the Environment
    Dr. P. Holland (New Zealand)
  3. Releases into the Environment of Natural Hormones from Humans, Wildlife and Livestock, their Excretion and their Initial Concentrations in Soil, Water, Food and Feed
    Dr. L. Shore (Israel)
  4. Concentration of Phytohormones in Food and Feed, their Release into the Environment, and their Initial Concentrations in Soil and Water
    Dr. P. Verger (France)
  5. Release into the Environment of Synthetic Hormones and Other Endocrine Active Pharmaceuticals from Humans and Livestock, their Excretion and their Initial Concentrations in Soil, Water, Food and Feed
    Dr. F. Ingerslev (Denmark)
  6. Releases of Industrial Chemicals by Different Pathways into the Environment and their Initial Concentrations in Soil and Water Contributor
    to be identified
  7. Releases of Pesticides by Agricultural Pathways into the Environment and their Initial Concentrations in Soil and Water
    Dr. K. Racke (USA)
  8. Degradation, Persistence and Accumulation of Endocrine Active Substances in Water and Soil
    Dr. A. Katayama (Japan)
  9. Metabolism of Endocrine Active Substances in Mammals
    Dr. N. Kurihara (Japan)
  10. Metabolism of Endocrine Active Substances in Aquatic and Terrestrial Organisms
    Dr. M. van den Berg (Netherland)
  11. Environmental Concentrations of Endocrine Active Substances
    Dr. T. Ternes (Germany)
  12. Environmental Exposure Modeling of Endocrine Active Substances
    Dr. P. de Voogt (Netherland)
  13. Prioritization of Information Needs to Improve Exposure Analysis and Global Conclusion
    Joint authorship

Topic 3 - Effects of Endocrine Active Chemicals in Rodents and Humans, and Risk Assessments for Humans
Coordinators: Prof. J. Ashby and Dr. J. Lamb

Humans
  1. Trends in Human Male Reproductive Health: Hypospadia, Testicular Cancer and Sperm Count
    Dr. N. Skkakebaek. (Denmark)
  2. Breast Cancer Incidence and Mortality and its Potential Relationship with Exposure to Environmental Hormones
    Dr. J. Li (USA)
  3. Predictions and Observations in Human Populations: Trends in Hormone-mediated Diseases in Developing Children
    Dr. M. New (USA)
  4. Human Health Effects of Endocrine Disrupting Chemicals: Weight of the Evidence
    Dr. J. Vos (Germany)
  5. Balancing of Beneficial and Adverse Effects of Hormonally Active Agents
    Dr. K. Setchell (USA)
  6. Hormonally Active Agents and Plausible Relationships to Adverse Effects on Human Health
    Dr. T. Inoue (Japan)

    Animals
  7. Biosynthesis, Metabolism and Transport of Steroid and Thyroid Hormones and Feedback Mechanisms: Rodent/Human Differences
    Dr. K. Pak (UK) or J. Katzenellenbogen (USA)
  8. Comparative Physiology of Reproductive Endocrine Systems and Hypophyseal Gonadal Functions in Rodents as Surrogates for Humans
    Dr. S. Tyl (USA)
  9. Significance of Experimental Studies for Assessing Adverse Effects of Endocrine, Active Substances in Humans
    Dr. E. Gray (USA)
  10. Evaluation of Observed Adverse Effects of Endocrine Active Substances on Reproduction and Development, Nervous and Immune Systems
    Dr. R. Chapin (USA)

    Risk Assessment
  11. Modification of Endocrine Active Potential by Mixtures (Synergism, Additivity and Antagonism)
    Dr. K. Gaido (USA)
  12. Determination of the TDI (Tolerable Daily Intake for Humans) and PNEC (Predicted No Effect Concentration in Environmental Species): Animal Models to Ensure Human Safety
    Dr. P. Fenner-Crisp (USA)
  13. Dose Response Assessment, Including Low Dose Extrapolations and Consideration of Hormesis
    Dr. H. Baron (USA)
  14. Use of NOAEL, Benchmark Dose, and Other Models for Human Risk Assessment of Hormonally Active Substances
    Dr. C. Kimmel (USA)
  15. Current Views on the Risk Assessment of Hormonally Active Substances
    Dr. S. Barlow (USA)
  16. Weighing the Evidence: Assessing Data Quality or Reliability for Responses to Hormonally Active Substance
    Dr. M. Shelby (USA)

Topic 4 - Effects of Endocrine Active Substances on Wildlife Species
Coordinator: Prof. J. Sumpter

  1. An Historical Perspective
    Prof. J. Sumpter (UK)
  2. Endocrine Disruption in Invertebrates: The TBT Story
    Dr. J. Oehlman (Germany)
  3. Endocrine Disruption in Freshwater Fish
    Dr. S. Jobling (UK)
  4. Endocrine Disruption in Marine Fish
    Dr. P. Matthiessen (UK)
  5. Deformed Frogs and Environmental Retinoids
    Dr. B. Blumberg (USA)
  6. Effects of Endocrine Disrupting Chemicals on Sex Determination and Differentiation in Reptiles
    Dr. L. Guillette (USA)
  7. Central Effects of Endocrine Disrupting Chemicals in Birds
    Dr. M. Fry (USA)
  8. Animal Models for the Study of Low Doses and Mixtures of Endocrine Disrupting Chemicals
    Dr. D. Crews (USA)
  9. Full Life Cycle Tests for Endocrine Disrupters Using Fish
    Dr. H. Yokota (Japan)
  10. Fate and Behavior of Endocrine Active Chemicals in the Environment
    Dr. A. Johnson (UK)
  11. Environmental Risk Assessment for Endocrine Active Substances Present in the Environment
    Dr. T. Bowmer (Netherland)
  12. A Governmental View of Endocrine Disrupters in Wildlife
    Dr. K. Cameron (UK)
  13. Endocrine Disruption in Wildlife: The Future
    Prof. J. Sumpter (UK)

 


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