Inspirations from nature. New reactions, new therapeutic leads,
and new drug delivery systems
P. A. Wender*, J. L. Baryza, S. E. Brenner, M. O. Clarke, G. G. Gamber,
J. C. Horan, T. C. Jessop, C. Kan, K. Pattabiraman, and T. J. Williams
*Department of Chemistry, Stanford University, Stanford,
CA 94305, USA
Abstract: Studies in our laboratory focus on problems in chemistry
(new reactions and synthesis), biology (novel modes of action), and
medicine (new therapeutic leads and drug delivery systems). These interconnected
and often synergistic activities are inspired by an interest in novel
structures, frequently from nature, that possess unique modes of action
and significant clinical potential. Described herein are some examples
of recent work from our laboratory that have led to new transition metal-catalyzed
reactions, a new and remarkably potent therapeutic lead, and new drug
delivery systems that are in clinical trials.
* Pure Appl.Chem. 75,
141-419 (2003). An issue of reviews and research papers based on
lectures presented at the 23rd IUPAC International Symposium on the
Chemistry of Natural Products, Florence, Italy, 28 July-2 August 2002.
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