Progress in fumagillin synthesis
W. Picoul, O. Bedel, A. Haudrechy, and Y. Langlois
Laboratoire de Synthèse des Substances Naturelles,Associé
au CNRS, Université de Paris-Sud, F-91405 Orsay, France
Abstract: After a brief account of the syntheses previously
described in literature, several approaches of the antiangiogenic sesquiterpene
fumagillin are described. Particularly, a ClaisenIreland ring-closing
metathesis strategy allowed the stereoselective preparation of several
advanced intermediates in the fumagillin synthesis.
*Pure Appl.Chem. 75,
141419 (2003). An issue of reviews and research papers based on
lectures presented at the 23rd IUPAC International Symposium on the
Chemistry of Natural Products, Florence, Italy, 28 July 2 August 2002.
Page last modified 15 April 2003.
Copyright © 2003 International Union of Pure and Applied Chemistry.
Questions or comments about IUPAC, please contact, the Secretariat.
Questions regarding the website, please contact web