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Pure Appl. Chem. 75(2-3), 273-278, 2003

Pure and Applied Chemistry

Vol. 75, Issue 2-3

Enantioselective synthesis and biological evaluation of a-hydroxylated lactone lignans

M. Sefkow, M. Raschke, and C. Steiner

1Universität Potsdam, Institut für Chemie, Karl-Liebknecht-Strasse 24-25,
D-14476 Golm, Germany; 2Universität Jena, Lehrstuhl für Ernährungstoxikologie, Dornburger Strasse 25, D-07743 Jena, Germany

Abstract: A short and efficient synthesis of enantiomerically pure a-hydroxylated lactone lignans starting from commercially available diisopropyl malate is presented. Stereoselective alkylation with various benzyl bromides and saponification yielded the corresponding succinic acids. Acetalization afforded the dioxolanones, which were stereoselectively alkylated. Reduction (and deprotection, where required) yielded the lactone lignans in up to 30 % overall yield. The inhibition of the proliferation of HT29 colon cancer cells was investigated. One lignane, bis-2,4,6 trimethylbenzyllactone lignan, was active (IC50 = 35 mM), whereas all other tested lignans were inactive within the investigated concentration range.

*Pure Appl.Chem. 75, 141419 (2003). An issue of reviews and research papers based on lectures presented at the 23rd IUPAC International Symposium on the Chemistry of Natural Products, Florence, Italy, 28 July 2 August 2002.


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