Exploitation of proteomics strategies in protein structure-function studies
G. Marino, P. Pucci, L. Birolo, and M. Ruoppolo
1Dipartimento di Chimica Organica e Biochimica, Facoltà
di Scienze Biotecnologiche, Università di Napoli “Federico
II”, Napoli, Italy; 2CEINGE, Biotecnologie Avanzate, scrl, Napoli,
Italy; 3Dipartimento di Biochimica e Biotecnologie Mediche, Università
di Napoli “Federico II”, Napoli, Italy
Abstract: Mass spectrometry plays a central role in
structural proteomics, particularly in highly intensive structural genomics
projects. This review paper reports some examples taken from recent
work from the authors' laboratory and is aimed at showing that modern
proteomics strategies are instrumental in the integration of structural
genomic projects in fields such as: (i) protein–protein interactions,
(ii) protein-DNA interactions, (iii) protein–ligand interactions,
and (iv) protein-folding intermediates.
*Pure Appl.Chem. 75,
141419 (2003). An issue of reviews and research papers based on
lectures presented at the 23rd IUPAC International Symposium on the
Chemistry of Natural Products, Florence, Italy, 28 July 2 August 2002.
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