Natural and totally synthetic receptors in the innovative design of HPLC chiral stationary phases
F. Gasparrini, I. D'Acquarica, D. Misiti, M. Pierini, and C. Villani
Dipartimento di Studi di Chimica e Tecnologia delle
Attive, Università “La Sapienza”, P. le A. Moro 5,
00185 Roma, Italy
Abstract: An overview is presented of the experimental
results obtained by our group in the design, realization, and applications
of high-performance liquid chromatography (HPLC) enantioselective stationary
phases based on surface-linked macrocyclic receptors. Macrocyclic synthetic
receptors and macrocyclic glycopeptide receptors have been grafted on
silica particles, and the resulting chiral stationary phases are used
to monitor differential associations of the enantiomers of selected
chiral guests with the immobilized hosts. Practical implications of
the chiral phases in enantioselective analysis and in the study of recognition
events are highlighted.
*Pure Appl.Chem. 75,
141419 (2003). An issue of reviews and research papers based on
lectures presented at the 23rd IUPAC International Symposium on the
Chemistry of Natural Products, Florence, Italy, 28 July 2 August 2002.
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