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Pure Appl. Chem. 75(11/12), 2419-2422, 2003

Pure and Applied Chemistry

Vol. 75, Issues 11-12

Application of toxicogenomics to the endocrine disruption issue

T. Shirai and M. Asamoto

Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1-Kawasumi, Nagoya 467-8601, Japan

Abstract: Toxicogenomics can be expected to be a useful method for detecting the carcinogenic potential of endocrine active substances (EASs) in the short term with the generation of understanding of mode-of-action and mechanisms when a reliable database with information about proteomics and informatics is established. At present, there are no concrete epidemiological data supporting any exogenous EAS contribution to hormone-related organ carcinogenesis in humans. However, with the establishment of appropriate animal models and analysis of genomic-scale gene expression, risk identification and evaluation should be facilitated within a relatively short period, and this approach eventually promises to contribute a great deal of risk management regarding EASs.

*Report from a SCOPE/IUPAC project: Implication of Endocrine Active Substances for Human and Wildlife (J. Miyamoto and J.Burger, editors). Other reports are published in this issue, pp. 1617-2615.


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