Pure Appl. Chem., 2001, Vol. 73, No. 10, pp. 1573-1577
http://dx.doi.org/10.1351/pac200173101573
Threading intercalation to double-stranded DNA and the application to DNA sensing. Electrochemical array technique
Abstract:
Electrochemical labeling of double-stranded (ds) DNA is achieved by redox-active DNA intercalators. Threading intercalators derived from naphthalenediimide appended with ferrocene reporter group in the side arms are particularly useful for this purpose. This allows a sensitive electrochemical detection of DNA hybridization on an array, providing a great potential for low-cost, high-throughput, and quick DNA screening technique in post-genome study.