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Pure Appl. Chem., 2006, Vol. 78, No. 2, pp. 425-434

Indium-catalyzed addition of carbon units to acetylenes: Development of a new C-C bond formation toward exploitation of chemical resources

Masaharu Nakamura

Department of Chemistry, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

Abstract: This account deals with an overview of the development of catalytic addition reactions of carbonyl compounds to alkynes catalyzed by a variety of indium salts. The new C-C bond formation reactions provide a powerful tool for α-functionalization of carbonyl compounds, including direct α-vinylation with acetylene, regioselective α-alkenylation, and α-ynenylation that can be applied to a modular synthesis of α-arylated β-keto esters.