Pure Appl. Chem., 2011, Vol. 83, No. 9, pp. 1709-1719
http://dx.doi.org/10.1351/PAC-CON-10-11-03
Published online 2011-03-29
Increased understanding of platinum anticancer chemistry
Abstract:
The development of a few worldwide routinely used Pt(II) coordination compounds is described from a mechanistic point of view and related to the molecular aspects of Pt-DNA binding. Mechanistic knowledge developed from these studies is applied nowadays for the design and synthesis of new bifunctional and trifunctional compounds, aimed for use as improved anticancer drugs.