Title: Post-genomic chemistry
Beletskaya, I. Bertini,
M. Blackburn, R.
Cunin, E. Efremenko,
J. Eichler, I.
Galaev, V. Gladyshev,
T. Haertle, A.
Karyakin, I. Kurochkin,
V. Poroikov, I.
Sakharov, F. Spener,
N. Voyer, and J.
Completion Date: 2005 - project completed
The objective is the analysis and discussion of the most promising
areas of bioorganic chemistry exploiting the informations provided by
the recent advances of functional genomics. Other objectives will aim
widest possible integration of research groups working in this area.
The network promoting worldwide collaboration and innovation in this
area will be organized during this conference.
Knowledge of human genome and of those of other organisms creates
number of new avenues for natural sciences. The main aim of the proposed
project is to analyze present and future impact of information yielded
by functional genomics on the modern chemistry and bioorganic chemistry
in particular. The principal axis of the conference will focus on the
analysis and exploitation of this information for the improvement of
human health. Specific working panels will be assembled to analyze and
discuss the following topics:
- Post-genomic strategies for drug design.
- Protein chemistry: sequence - structure - function relationships.
- Proteins containing chemically modified amino acids: (natural proteins
containing unnatural amino acids).
- Post-genomic biocatalysis: identification of the enzyme active
sites and prediction of catalytic properties from gene sequences.
- Multi-array analysis. New protein and DNA biochip technologies.
- Non-invasive monitoring of blood chemistry.
- 'In silico' modeling of a cell: construction of "living" cells
in computer. Biokinetic computer models for studies of gene expression
In developing this project, a mini-workshop was held 68 September
2003 in Moscow, which allowed experts to exchange views on chemistry
in the post genomic era. In particular, they discussed the implication
of advances in genomics, proteomics, biomimetics, and biological and
> See update as reported in Chem.
Project completed - IUPAC Technical Report published in Pure
77(9), 1641-1654, 2005
Last update: 3 October 2005