Cooperation of metals with electroactive ligands of biochemical
relevance: Beyond metalloporphyrins
W. Kaim and B. Schwederski
Institut für Anorganische Chemie, Universität
Stuttgart, Pfaffenwaldring 55, D-70550 Stuttgart, Germany
Abstract:
In addition to the widely studied biometal complexes of tetrapyrrole
ligands such as hemes (Fe), cobalamins (Co), and factor F430 (Ni), there
are other, more recently established systems in which transition metals
and redox-active cofactors such as pterins, flavins, quinones, or phenoxyl
radicals cooperate in electron transfer and substrate activation. The
cases of the molybdenum or tungsten containing oxotransferases involving
pyranopterin as essential ligand and the copper-dependent quinoproteins
such as amine oxidases will be discussed. The structural and functional
description of these systems will be complemented by results from model
studies.
*Plenary lecture presented at the 2nd Santa Mar�a Workshop
on Chemistry Devoted to Bioinorganic Chemistry, Santa Mar�a del Mar,
Havana, Cuba, 7-11 July 2003. Other presentations are published in this
issue, pp. 321-388.
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